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In addition, a study conducted in BV2 murine microglia cells, which served as a representative cell specimen for brain microglia, showed that the upregulation of antioxidant/detoxification proteins by SFN was associated with enhanced resistance of microglial cells to heat-induced toxicity and removal of ROS during microglial cell activation (90)

J Rheumatol 40(7):10891096 Kyoung-Jin M, Kyounghwa C, Taeg KK (2011) Withaferin A down-regulates lipopolysaccharide-induced cyclooxygenase-2 expression and PGE2 production through the inhibition of STAT1/3 activation in microglial cells

Genes & Dis 10(4):13671401 Andreyev J, Ross P, Donnellan C, Lennan E, Leonard P, Waters C et al (2014) Guidance on the management of diarrhoea during cancer chemotherapy

Gradual implementation of this approach may further enhance reproductive and endocrine outcomes in women with PCOS

Just so you know, beeswax is not vegan since it is animal-derived